![]() ![]() Unfortunately, most of the available tools for ROC analysis are implemented into commercially available software packages, or are plugins in statistical software, which are not always the easiest to use. For example, in virtual drug screening ROC curves are very often used to visualize the efficiency of the used application to separate active ligands from inactive molecules. Receiver operating characteristics ( ROC) curve with the calculation of area under curve ( AUC) is a useful tool to evaluate the performance of biomedical and chemoinformatics data. Lätti, Sakari Niinivehmas, Sanna Pentikäinen, Olli T Rocker: Open source, easy-to-use tool for AUC and enrichment calculations and ROC visualization. We also apply the proposed method to synthesized data and two real examples to illustrate its usefulness in practice. The test also implicitly analyzes the equality of two commonly used binormal ROC curves at every operating point. Because high specificity is important in many classification tasks, such as medical diagnosis, this is an appealing characteristic. Larger s AUC implies larger partial AUC at the range of low false-positive rates in this case. The new procedure is shown, numerically, to be effective in terms of power under a wide range of scenarios additionally, it outperforms two conventional ROC-type tests, especially when two ROC curves cross each other and have similar AUCs. In order to detect differences between ROC curves in such situations, a two-stage nonparametric test that uses a shifted area under the ROC curve (s AUC), along with AUCs, is proposed for paired designs. ![]() ![]() However, this index is less informative when two ROC curves cross and have similar AUCs. Statistical tests based on it for analyzing the difference have been well developed. The area under the receiver operating characteristic ( ROC) curve ( AUC) is a popularly used index when comparing two ROC curves. Yu, Wenbao Park, Eunsik Chang, Yuan-Chin Ivan Comparison of Paired ROC Curves through a Two-Stage Test. ![]()
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